Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

B Chen, P Yu, WN Chan, F Xie, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Targeting tumor microenvironment by metal peroxide nanoparticles in cancer therapy

SN Mbugua - Bioinorganic Chemistry and Applications, 2022 - Wiley Online Library
Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low
acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These …

Zinc–Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy …

Y Lu, Y Chen, G Hou, H Lei, L Liu, X Huang, S Sun… - ACS …, 2024 - ACS Publications
Immunotherapy has emerged as a potential approach for breast cancer treatment. However,
the rigid stromal microenvironment and low immunogenicity of breast tumors strongly reduce …

Calcium's Role and Signaling in Aging Muscle, Cellular Senescence, and Mineral Interactions

K Terrell, S Choi, S Choi - International Journal of Molecular Sciences, 2023 - mdpi.com
Calcium research, since its pivotal discovery in the early 1800s through the heating of
limestone, has led to the identification of its multi-functional roles. These include its functions …

The role of selenium in atherosclerosis development, progression, prevention and treatment

SA Dabravolski, VN Sukhorukov, AA Melnichenko… - Biomedicines, 2023 - mdpi.com
Selenium is an essential trace element that is essential for various metabolic processes,
protection from oxidative stress and proper functioning of the cardiovascular system. Se …

Biodegradable Zn‐5Dy Alloy with Enhanced Osteo/Angio‐Genic Activity and Osteointegration Effect via Regulation of SIRT4‐Dependent Mitochondrial Function

Y Han, X Tong, R Zhou, Y Wang, Y Chen… - Advanced …, 2024 - Wiley Online Library
Abstract Zinc (Zn)–dysprosium (Dy) binary alloys are promising biodegradable bone fracture
fixation implants owing to their attractive biodegradability and mechanical properties …

Zinc (II) Carboxylate Coordination Polymers with Versatile Applications

G Vasile Scaeteanu, C Maxim, M Badea, R Olar - Molecules, 2023 - mdpi.com
This review considers the applications of Zn (II) carboxylate-based coordination polymers
(Zn-CBCPs), such as sensors, catalysts, species with potential in infections and cancers …

Recent progress in the role of endogenous metal ions in doxorubicin-induced cardiotoxicity

N Zhou, S Wei, T Sun, S Xie, J Liu, W Li… - Frontiers in …, 2023 - frontiersin.org
Doxorubicin is a widely used anticancer drug in clinical practice for the treatment of various
human tumors. However, its administration is associated with cardiotoxicity. Administration …

Contaminant metals as cardiovascular risk factors: a scientific statement from the American Heart Association

GA Lamas, A Bhatnagar, MR Jones… - Journal of the …, 2023 - Am Heart Assoc
Exposure to environmental pollutants is linked to increased risk of cardiovascular disease.
Beyond the extensive evidence for particulate air pollution, accumulating evidence supports …

The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart

AM Dorward, AJ Stewart, SJ Pitt - Journal of General Physiology, 2023 - rupress.org
Increasing evidence suggests that Zn2+ acts as a second messenger capable of
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …