Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …
key observation is the disruption of cellular homeostasis, often coinciding with disease …
Targeting tumor microenvironment by metal peroxide nanoparticles in cancer therapy
SN Mbugua - Bioinorganic Chemistry and Applications, 2022 - Wiley Online Library
Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low
acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These …
acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These …
Zinc–Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy …
Y Lu, Y Chen, G Hou, H Lei, L Liu, X Huang, S Sun… - ACS …, 2024 - ACS Publications
Immunotherapy has emerged as a potential approach for breast cancer treatment. However,
the rigid stromal microenvironment and low immunogenicity of breast tumors strongly reduce …
the rigid stromal microenvironment and low immunogenicity of breast tumors strongly reduce …
Calcium's Role and Signaling in Aging Muscle, Cellular Senescence, and Mineral Interactions
Calcium research, since its pivotal discovery in the early 1800s through the heating of
limestone, has led to the identification of its multi-functional roles. These include its functions …
limestone, has led to the identification of its multi-functional roles. These include its functions …
The role of selenium in atherosclerosis development, progression, prevention and treatment
SA Dabravolski, VN Sukhorukov, AA Melnichenko… - Biomedicines, 2023 - mdpi.com
Selenium is an essential trace element that is essential for various metabolic processes,
protection from oxidative stress and proper functioning of the cardiovascular system. Se …
protection from oxidative stress and proper functioning of the cardiovascular system. Se …
Biodegradable Zn‐5Dy Alloy with Enhanced Osteo/Angio‐Genic Activity and Osteointegration Effect via Regulation of SIRT4‐Dependent Mitochondrial Function
Y Han, X Tong, R Zhou, Y Wang, Y Chen… - Advanced …, 2024 - Wiley Online Library
Abstract Zinc (Zn)–dysprosium (Dy) binary alloys are promising biodegradable bone fracture
fixation implants owing to their attractive biodegradability and mechanical properties …
fixation implants owing to their attractive biodegradability and mechanical properties …
Zinc (II) Carboxylate Coordination Polymers with Versatile Applications
This review considers the applications of Zn (II) carboxylate-based coordination polymers
(Zn-CBCPs), such as sensors, catalysts, species with potential in infections and cancers …
(Zn-CBCPs), such as sensors, catalysts, species with potential in infections and cancers …
Recent progress in the role of endogenous metal ions in doxorubicin-induced cardiotoxicity
N Zhou, S Wei, T Sun, S Xie, J Liu, W Li… - Frontiers in …, 2023 - frontiersin.org
Doxorubicin is a widely used anticancer drug in clinical practice for the treatment of various
human tumors. However, its administration is associated with cardiotoxicity. Administration …
human tumors. However, its administration is associated with cardiotoxicity. Administration …
Contaminant metals as cardiovascular risk factors: a scientific statement from the American Heart Association
GA Lamas, A Bhatnagar, MR Jones… - Journal of the …, 2023 - Am Heart Assoc
Exposure to environmental pollutants is linked to increased risk of cardiovascular disease.
Beyond the extensive evidence for particulate air pollution, accumulating evidence supports …
Beyond the extensive evidence for particulate air pollution, accumulating evidence supports …
The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart
AM Dorward, AJ Stewart, SJ Pitt - Journal of General Physiology, 2023 - rupress.org
Increasing evidence suggests that Zn2+ acts as a second messenger capable of
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …