The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Obesity-related disease complications reduce life quality and expectancy and increase
health-care costs. Some studies have suggested that obesity not always entails metabolic …

Objective: Lipodystrophy syndromes are extremely rare disorders of deficient body fat
associated with potentially serious metabolic complications, including diabetes …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-
Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Background The adipocyte hormone leptin is important in regulating energy homeostasis.
Since severe lipodystrophy is associated with leptin deficiency, insulin resistance …

Lipodystrophies, heterogeneous acquired or inherited disorders characterized by the
selective loss of adipose tissue, predispose affected patients to insulin resistance and its …