[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications

CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …

Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines

X Liu, Y Zhang, S Zhou, L Dain, L Mei, G Zhu - Journal of Controlled …, 2022 - Elsevier
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …

The expanding regulatory mechanisms and cellular functions of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …

[HTML][HTML] The biogenesis, functions, and challenges of circular RNAs

X Li, L Yang, LL Chen - Molecular cell, 2018 - cell.com
Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …

[HTML][HTML] Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

The biogenesis and emerging roles of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2016 - nature.com
Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of
thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels …

A 360 view of circular RNAs: From biogenesis to functions

JE Wilusz - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
The first circular RNA (circRNA) was identified more than 40 years ago, but it was only
recently appreciated that circRNAs are common outputs of many eukaryotic protein‐coding …

Circular RNA: a new star of noncoding RNAs

S Qu, X Yang, X Li, J Wang, Y Gao, R Shang, W Sun… - Cancer letters, 2015 - Elsevier
Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a
covalently closed continuous loop and are highly represented in the eukaryotic …