Challenges and strategies for developing recombinant vaccines against leptospirosis: Role of expression platforms and adjuvants in achieving protective efficacy
NR de Oliveira, FDS Santos, VAC Dos Santos… - Pathogens, 2023 - mdpi.com
The first leptospiral recombinant vaccine was developed in the late 1990s. Since then,
progress in the fields of reverse vaccinology (RV) and structural vaccinology (SV) has …
progress in the fields of reverse vaccinology (RV) and structural vaccinology (SV) has …
An overview of human leptospirosis vaccine design and future perspectives
CR Felix, BS Siedler, LN Barbosa… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: It's been 20 years since the first report of a recombinant vaccine that protected
against leptospirosis. Since then, numerous recombinant vaccines have been evaluated; …
against leptospirosis. Since then, numerous recombinant vaccines have been evaluated; …
Characterization of novel nuclease and protease activities among Leptospiral immunoglobulin-like proteins
Bacterial immunoglobulin-like (BIg) domain containing proteins play a variety of biological
functions. Leptospiral Immunoglobulin-like (Lig) proteins are well-known virulence factors …
functions. Leptospiral Immunoglobulin-like (Lig) proteins are well-known virulence factors …
Adjuvanted leptospiral vaccines: Challenges and future development of new leptospirosis vaccines
Leptospirosis is a neglected infectious disease of global importance. Vaccination is the most
viable strategy for the control of leptospirosis, but in spite of efforts for the development of an …
viable strategy for the control of leptospirosis, but in spite of efforts for the development of an …
Bovine immune response to leptospira antigen in different novel adjuvants and vaccine delivery platforms
Leptospirosis is a global zoonosis causing significant economic losses for cattle production.
Current cattle vaccines against leptospirosis need improvement to provide efficacy against …
Current cattle vaccines against leptospirosis need improvement to provide efficacy against …
Crystal structure of a variable region segment of Leptospira host-interacting outer surface protein, LigA, reveals the orientation of Ig-like domains
P Kumar, P Vyas, SM Faisal, YF Chang… - International Journal of …, 2023 - Elsevier
Leptospiral immunoglobulin-like (Lig) protein family is a surface-exposed protein from the
pathogenic Leptospira. The Lig protein family has been identified as an essential virulence …
pathogenic Leptospira. The Lig protein family has been identified as an essential virulence …