Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Cortactin fulfills many functions in various cell types. These functions have been considered
to derive from its ability to activate the Actin-related protein 2/3 (Arp2/3) complex, and are …

The Arp2/3 complex consists of seven evolutionarily conserved subunits (Arp2, Arp3 and
ARPC1–5) and plays an essential role in generating branched actin filament networks …

Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many
cancers. Whether these events are interconnected and the driving mechanism coordinating …

Currently, cancer metastases remain a major clinical problem that highlights the importance
of recognition of the metastatic process in cancer diagnosis and treatment. A critical process …

Two types of sequences, proline-rich domains (PRDs) and the WASP-homology 2 (WH2)
domain, are found in most actin filament nucleation and elongation factors discovered thus …

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central
player in models of protrusive force production via the dynamic actin network. Here, we …

WASP‐family proteins are known to promote assembly of branched actin networks by
stimulating the filament‐nucleating activity of the Arp2/3 complex. Here, we show that WASP …

Cortactin, a substrate of sarcoma (Src) kinases, is an actin-binding protein that is involved in
cytoskeletal regulation, and is frequently overexpressed in cancer cells. Binding to the actin …