Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …

Phosphatidic acid (PA) has only recently been identified as an important signaling molecule
in both plants and animals. Nonetheless, it already promises to rival the importance of the …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

Phox homology (PX) domains are membrane interacting domains that bind to
phosphatidylinositol phospholipids or phosphoinositides, markers of organelle identity in the …

Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the glycerolipid
phosphatidylcholine, resulting in the production of phosphatidic acid and free choline …

Abstract Phospholipases (PLC, PLD and PLA) are essential mediators of intracellular and
intercellular signalling. They can function as phospholipid-hydrolysing enzymes that can …

Phosphoinositide (PI) lipids are essential components of eukaryotic cell membranes. They
are produced by mono-, bis-and trisphosphorylation of the inositol headgroup of …

Phosphoinositides (PIs) are phosphorylated derivatives of phosphatidylinositol (PtdIns) that
regulate many cellular and physiological processes. Most PIs act by serving as membrane …