Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

Summary Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find
that central application of IL-6 in mice suppresses feeding and improves glucose tolerance …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Obesity is often associated with cognitive and mood disorders. Recent evidence suggests
that obesity may cause hypothalamic inflammation. Our aim was to investigate the …

High-intensity exercise suppresses appetite partly through changes in peripheral appetite-
regulating hormones. Lactate and IL-6 mediate the release of these hormones in animal/cell …

Glucagon-like peptide 1 (GLP-1), produced in the intestine and the brain, can stimulate
insulin secretion from the pancreas and alleviate type 2 diabetes. The cytokine interleukin-6 …

A high-fat diet (HFD) is linked with cytokines production by non-neuronal cells within the
hypothalamus, which mediates metabolic inflammation. These cytokines then activate …

Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated
that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating …