[HTML][HTML] A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

H Kadry, B Noorani, L Cucullo - Fluids and Barriers of the CNS, 2020 - Springer
The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

[HTML][HTML] Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

G Barbara, MR Barbaro, D Fuschi, M Palombo… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

[HTML][HTML] Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases

A Vojdani, E Vojdani, D Kharrazian - Frontiers in Immunology, 2021 - frontiersin.org
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2
protein antibodies and human tissue antigens, and whether molecular mimicry between …

The blood–brain barrier in health and disease: Important unanswered questions

CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

R Hashimoto, J Takahashi, K Shirakura, R Funatsu… - Science …, 2022 - science.org
In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers …

Statistical analysis of spatial expression patterns for spatially resolved transcriptomic studies

S Sun, J Zhu, X Zhou - Nature methods, 2020 - nature.com
Identifying genes that display spatial expression patterns in spatially resolved transcriptomic
studies is an important first step toward characterizing the spatial transcriptomic landscape …

[HTML][HTML] Claudin-5: gatekeeper of neurological function

C Greene, N Hanley, M Campbell - Fluids and Barriers of the CNS, 2019 - Springer
Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer's disease

Q Wang, X Huang, Y Su, G Yin, S Wang, B Yu, H Li… - Brain, 2022 - academic.oup.com
Alzheimer's disease is a neurodegenerative disorder that causes age-dependent
neurological and cognitive declines. The treatments for Alzheimer's disease pose a …

Development and cell biology of the blood-brain barrier

UH Langen, S Ayloo, C Gu - Annual review of cell and …, 2019 - annualreviews.org
The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

The blood–brain barrier

R Daneman, A Prat - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …