Bidirectional microglia–neuron communication in health and disease
Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
Innate immune responses to trauma
M Huber-Lang, JD Lambris, PA Ward - Nature immunology, 2018 - nature.com
Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …
The S100B story: from biomarker to active factor in neural injury
F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …
Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
N Hegdekar, C Sarkar, S Bustos, RM Ritzel… - Autophagy, 2023 - Taylor & Francis
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …
contributes to long-term tissue damage and poor functional outcomes. However, the …
Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1 …
X Chen, C Chen, S Fan, S Wu, F Yang, Z Fang… - Journal of …, 2018 - Springer
Background Microglial polarization and the subsequent neuroinflammatory response are
contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile …
contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile …
The immunological response to traumatic brain injury
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the
developed world. The accuracy of early outcome-prediction remains poor even when all …
developed world. The accuracy of early outcome-prediction remains poor even when all …
Neurological consequences of COVID-19: what have we learned and where do we go from here?
Abstract The coronavirus disease-19 (COVID-19) pandemic is an unprecedented worldwide
health crisis. COVID-19 is caused by SARS-CoV-2, a highly infectious pathogen that is …
health crisis. COVID-19 is caused by SARS-CoV-2, a highly infectious pathogen that is …
[HTML][HTML] Surface-fill H2S-releasing silk fibroin hydrogel for brain repair through the repression of neuronal pyroptosis
X Chen, X Huang, C Liu, S Li, Z Yang, F Zhang… - Acta Biomaterialia, 2022 - Elsevier
Traumatic brain injury (TBI) remains the major cause of disability and mortality worldwide
due to the persistent neuroinflammation and neuronal death induced by TBI. Among them …
due to the persistent neuroinflammation and neuronal death induced by TBI. Among them …
Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury
B Lv, X Zhang, J Yuan, Y Chen, H Ding, X Cao… - Stem Cell Research & …, 2021 - Springer
The spinal cord is part of the central nervous system (CNS) and serves to connect the brain
to the peripheral nervous system and peripheral tissues. The cell types that primarily …
to the peripheral nervous system and peripheral tissues. The cell types that primarily …