The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …

Immune cells can sense and respond to biophysical cues—from dynamic forces to spatial
features—during their development, activation, differentiation and expansion. These …

Recent studies indicate that the adaptive immune system plays a role in Lewy body
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …

T cells use their T‐cell receptors (TCRs) to discriminate between lower‐affinity self and
higher‐affinity foreign peptide major‐histocompatibility‐complexes (pMHCs) based on the …

Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …

Quantifying small, rapidly progressing three-dimensional forces generated by cells remains
a major challenge towards a more complete understanding of mechanobiology. Traction …

Quantifying small, rapidly evolving forces generated by cells is a major challenge for the
understanding of biomechanics and mechanobiology in health and disease. Traction force …

Activation of naive T cells by antigen-presenting cells (APCs) is an essential step in
mounting an adaptive immune response. It is known that antigen recognition and T cell …

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been
implicated in T-cell antigen recognition, yet their magnitude, spread, and dynamical …

Immune responses are directed by the complex interactions of different cell types, including
T cells and Natural Killer (NK) cells, with a key type of interaction being the formation of …