Mechanisms of virus assembly

JD Perlmutter, MF Hagan - Annual review of physical chemistry, 2015 - annualreviews.org
Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell
called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review …

[PDF][PDF] Recent advances in coarse-grained modeling of virus assembly

MF Hagan, R Zandi - Current opinion in virology, 2016 - Elsevier
In many virus families, tens to thousands of proteins assemble spontaneously into a capsid
(protein shell) while packaging the genomic nucleic acid. This review summarizes recent …

Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly

JMA Grime, JF Dama, BK Ganser-Pornillos… - Nature …, 2016 - nature.com
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation,
many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral …

Cell-free TXTL synthesis of infectious bacteriophage T4 in a single test tube reaction

M Rustad, A Eastlund, P Jardine, V Noireaux - Synthetic Biology, 2018 - academic.oup.com
The bottom-up construction of biological entities from genetic information provides a broad
range of opportunities to better understand fundamental processes within living cells, as well …

Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions

S Guo, I Saha, S Saffarian, ME Johnson - elife, 2023 - elifesciences.org
For HIV virions to become infectious, the immature lattice of Gag polyproteins attached to the
virion membrane must be cleaved. Cleavage cannot initiate without the protease formed by …

Making microenvironments: A look into incorporating macromolecular crowding into in vitro experiments, to generate biomimetic microenvironments which are …

P Benny, M Raghunath - Journal of tissue engineering, 2017 - journals.sagepub.com
Biomimetic microenvironments are key components to successful cell culture and tissue
engineering in vitro. One of the most accurate biomimetic microenvironments is that made by …

Using Markov state models to study self-assembly

MR Perkett, MF Hagan - The Journal of chemical physics, 2014 - pubs.aip.org
Markov state models (MSMs) have been demonstrated to be a powerful method for
computationally studying intramolecular processes such as protein folding and …

Viruses, artificial viruses and virus‐based structures for biomedical applications

P van Rijn, R Schirhagl - Advanced healthcare materials, 2016 - Wiley Online Library
Nanobiomaterials such as virus particles and artificial virus particles offer tremendous
opportunities to develop new biomedical applications such as drug‐or gene‐delivery …

Multiscale molecular dynamics simulation approaches to the structure and dynamics of viruses

RG Huber, JK Marzinek, DA Holdbrook… - Progress in Biophysics …, 2017 - Elsevier
Viral pathogens are a significant source of human morbidity and mortality, and have a major
impact on societies and economies around the world. One of the challenges inherent in …

Virus mechanics under molecular crowding

C Zeng, L Scott, A Malyutin, R Zandi… - The Journal of …, 2021 - ACS Publications
Viruses avoid exposure of the viral genome to harmful agents with the help of a protective
protein shell known as the capsid. A secondary effect of this protective barrier is that …