Mechanisms of virus assembly
JD Perlmutter, MF Hagan - Annual review of physical chemistry, 2015 - annualreviews.org
Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell
called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review …
called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review …
[PDF][PDF] Recent advances in coarse-grained modeling of virus assembly
In many virus families, tens to thousands of proteins assemble spontaneously into a capsid
(protein shell) while packaging the genomic nucleic acid. This review summarizes recent …
(protein shell) while packaging the genomic nucleic acid. This review summarizes recent …
Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
JMA Grime, JF Dama, BK Ganser-Pornillos… - Nature …, 2016 - nature.com
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation,
many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral …
many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral …
Cell-free TXTL synthesis of infectious bacteriophage T4 in a single test tube reaction
The bottom-up construction of biological entities from genetic information provides a broad
range of opportunities to better understand fundamental processes within living cells, as well …
range of opportunities to better understand fundamental processes within living cells, as well …
Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions
For HIV virions to become infectious, the immature lattice of Gag polyproteins attached to the
virion membrane must be cleaved. Cleavage cannot initiate without the protease formed by …
virion membrane must be cleaved. Cleavage cannot initiate without the protease formed by …
Making microenvironments: A look into incorporating macromolecular crowding into in vitro experiments, to generate biomimetic microenvironments which are …
P Benny, M Raghunath - Journal of tissue engineering, 2017 - journals.sagepub.com
Biomimetic microenvironments are key components to successful cell culture and tissue
engineering in vitro. One of the most accurate biomimetic microenvironments is that made by …
engineering in vitro. One of the most accurate biomimetic microenvironments is that made by …
Using Markov state models to study self-assembly
MR Perkett, MF Hagan - The Journal of chemical physics, 2014 - pubs.aip.org
Markov state models (MSMs) have been demonstrated to be a powerful method for
computationally studying intramolecular processes such as protein folding and …
computationally studying intramolecular processes such as protein folding and …
Viruses, artificial viruses and virus‐based structures for biomedical applications
P van Rijn, R Schirhagl - Advanced healthcare materials, 2016 - Wiley Online Library
Nanobiomaterials such as virus particles and artificial virus particles offer tremendous
opportunities to develop new biomedical applications such as drug‐or gene‐delivery …
opportunities to develop new biomedical applications such as drug‐or gene‐delivery …
Multiscale molecular dynamics simulation approaches to the structure and dynamics of viruses
RG Huber, JK Marzinek, DA Holdbrook… - Progress in Biophysics …, 2017 - Elsevier
Viral pathogens are a significant source of human morbidity and mortality, and have a major
impact on societies and economies around the world. One of the challenges inherent in …
impact on societies and economies around the world. One of the challenges inherent in …
Virus mechanics under molecular crowding
Viruses avoid exposure of the viral genome to harmful agents with the help of a protective
protein shell known as the capsid. A secondary effect of this protective barrier is that …
protein shell known as the capsid. A secondary effect of this protective barrier is that …