Mechanisms of taxane resistance
SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
[HTML][HTML] Molecular insights into NF2/Merlin tumor suppressor function
J Cooper, FG Giancotti - FEBS letters, 2014 - Elsevier
The FERM domain protein Merlin, encoded by the NF2 tumor suppressor gene, regulates
cell proliferation in response to adhesive signaling. The growth inhibitory function of Merlin …
cell proliferation in response to adhesive signaling. The growth inhibitory function of Merlin …
The Hippo signaling pathway in drug resistance in cancer
R Zeng, J Dong - Cancers, 2021 - mdpi.com
Simple Summary Although great breakthroughs have been made in cancer treatment
following the development of targeted therapy and immune therapy, resistance against anti …
following the development of targeted therapy and immune therapy, resistance against anti …
Sensing the local environment: actin architecture and Hippo signalling
The Hippo network is a major conserved growth suppressor pathway that participates in
organ size control during development and prevents tumour formation during adult …
organ size control during development and prevents tumour formation during adult …
Tumour suppressor genes in chemotherapeutic drug response
D Lai, S Visser-Grieve, X Yang - Bioscience reports, 2012 - portlandpress.com
Since cancer is one of the leading causes of death worldwide, there is an urgent need to find
better treatments. Currently, the use of chemotherapeutics remains the predominant option …
better treatments. Currently, the use of chemotherapeutics remains the predominant option …
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus
W Li, J Cooper, MA Karajannis, FG Giancotti - EMBO reports, 2012 - embopress.org
Inhibition of proliferation by cell‐to‐cell contact is essential for tissue organization, and its
disruption contributes to tumorigenesis. The FERM domain protein Merlin, encoded by the …
disruption contributes to tumorigenesis. The FERM domain protein Merlin, encoded by the …
An evolutionary shift in the regulation of the Hippo pathway between mice and flies
The Hippo pathway plays a key role in controlling organ growth in many animal species and
its deregulation is associated with different types of cancer. Understanding the regulation of …
its deregulation is associated with different types of cancer. Understanding the regulation of …
The Hippo pathway in colorectal cancer
PM Wierzbicki, A Rybarczyk - Folia histochemica et …, 2015 - journals.viamedica.pl
Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases
worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with …
worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with …
The H ippo pathway in chemotherapeutic drug resistance
Y Zhao, X Yang - International journal of cancer, 2015 - Wiley Online Library
Chemotherapy is one of the major treatments for cancer patients. Although
chemotherapeutic drugs can sometimes effectively suppress tumor growth in cancer …
chemotherapeutic drugs can sometimes effectively suppress tumor growth in cancer …
Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy
JH Xu, SL Hu, GD Shen, G Shen - Cancer cell international, 2016 - Springer
Objectives Paclitaxel (PTX) is frequently used in the clinical treatment of solid tumors. But the
PTX-resistance is a great obstacle in cancer treatment. Exploration of the mechanisms of …
PTX-resistance is a great obstacle in cancer treatment. Exploration of the mechanisms of …