It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor
neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43 …

Zebrafish are widely considered an excellent vertebrate model for studying the
pathogenesis of human diseases because of their transparency of embryonic development …

It has been more than 10 years since the hopes for disease modeling and drug discovery
using induced pluripotent stem cell (iPSC) technology boomed. Recently, clinical trials have …

Background Severe peripheral nerve damage always requires surgical treatment.
Autologous nerve transplantation is a standard treatment, but it is not sufficient due to length …

Although methods for generating human induced pluripotent stem cell (hiPSC)-derived
motor nerve organoids are well established, those for sensory nerve organoids are not …

Neurodegenerative diseases (NDDs) include a large group of debilitating and still incurable
pathologies with a progressive degenerative clinical course, which cause the death of …

The neurodegenerative disease amyotrophic lateral sclerosis (ALS) is characteristically
heterogeneous in both genetic causality and cellular pathology. In ALS, the upper and lower …

Background The most serious condition of male infertility is complete Sertoli cell-only
syndrome (SCOS), which refers to the lack of all spermatogenic cells in the testes. The …