[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Glaucoma: the retina and beyond
BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
[HTML][HTML] SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open …
MA Kass, DK Heuer, EJ Higginbotham… - Archives of …, 2002 - jamanetwork.com
Background Primary open-angle glaucoma (POAG) is one of the leading causes of
blindness in the United States and worldwide. Three to 6 million people in the United States …
blindness in the United States and worldwide. Three to 6 million people in the United States …
Glutathione dysregulation and the etiology and progression of human diseases
Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH …
differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH …
The investigation of acute optic neuritis: a review and proposed protocol
A Petzold, MP Wattjes, F Costello… - Nature Reviews …, 2014 - nature.com
Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple
sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of …
sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of …
Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT
DL Budenz, DR Anderson, R Varma, J Schuman… - Ophthalmology, 2007 - Elsevier
PURPOSE: To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial
length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by …
length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by …
A framework for comparing structural and functional measures of glaucomatous damage
While it is often said that structural damage due to glaucoma precedes functional damage, it
is not always clear what this statement means. This review has two purposes: first, to show …
is not always clear what this statement means. This review has two purposes: first, to show …
A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study
T Krupin, JM Liebmann, DS Greenfield, R Ritch… - American journal of …, 2011 - Elsevier
PURPOSE:: To compare the alpha2-adrenergic agonist brimonidine tartrate 0.2% to the beta-
adrenergic antagonist timolol maleate 0.5% in preserving visual function in low-pressure …
adrenergic antagonist timolol maleate 0.5% in preserving visual function in low-pressure …
Axon regeneration in the mammalian optic nerve
PR Williams, LI Benowitz… - Annual review of vision …, 2020 - annualreviews.org
The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …
functional defects observed after traumatic injury, in degenerative diseases such as …