An update on Sec61 channel functions, mechanisms, and related diseases
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …
protein translocon, which facilitates membrane integration or translocation of almost every …
Targeting and translocation of proteins to the endoplasmic reticulum at a glance
N Aviram, M Schuldiner - Journal of cell science, 2017 - journals.biologists.com
The evolutionary emergence of organelles was a defining process in diversifying
biochemical reactions within the cell and enabling multicellularity. However …
biochemical reactions within the cell and enabling multicellularity. However …
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
F Fumagalli, J Noack, TJ Bergmann, E Cebollero… - Nature cell …, 2016 - nature.com
The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …
ER homeostasis activates stress programs collectively called the unfolded protein response …
ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress
The endoplasmic reticulum (ER) produces about 40% of the nucleated cell's proteome. ER
size and content in molecular chaperones increase upon physiologic and pathologic …
size and content in molecular chaperones increase upon physiologic and pathologic …
A clearer picture of the ER translocon complex
M Gemmer, F Förster - Journal of cell science, 2020 - journals.biologists.com
The endoplasmic reticulum (ER) translocon complex is the main gate into the secretory
pathway, facilitating the translocation of nascent peptides into the ER lumen or their …
pathway, facilitating the translocation of nascent peptides into the ER lumen or their …
The largely unexplored biology of small proteins in pro‐and eukaryotes
R Steinberg, HG Koch - The FEBS journal, 2021 - Wiley Online Library
The large abundance of small open reading frames (smORFs) in prokaryotic and eukaryotic
genomes and the plethora of smORF‐encoded small proteins became only apparent with …
genomes and the plethora of smORF‐encoded small proteins became only apparent with …
An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum
The heterotrimeric Sec61 complex is a major site for the biogenesis of transmembrane
proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic …
proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic …
Take me home, protein roads: Structural insights into signal peptide interactions during ER translocation
AM Liaci, F Förster - International Journal of Molecular Sciences, 2021 - mdpi.com
Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable
signal sequences target roughly a quarter of the human proteome to the ER. These short …
signal sequences target roughly a quarter of the human proteome to the ER. These short …
SRPassing co-translational targeting: the role of the signal recognition particle in protein targeting and mRNA protection
MK Kellogg, SC Miller, EB Tikhonova… - International journal of …, 2021 - mdpi.com
Signal recognition particle (SRP) is an RNA and protein complex that exists in all domains of
life. It consists of one protein and one noncoding RNA in some bacteria. It is more complex …
life. It consists of one protein and one noncoding RNA in some bacteria. It is more complex …
Membrane protein biogenesis at the ER: The highways and byways
The Sec61 complex is the major protein translocation channel of the endoplasmic reticulum
(ER), where it plays a central role in the biogenesis of membrane and secretory proteins …
(ER), where it plays a central role in the biogenesis of membrane and secretory proteins …