[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening

H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

[HTML][HTML] Cohort-based long-term ozone exposure-associated mortality risks with adjusted metrics: a systematic review and meta-analysis

HZ Sun, P Yu, C Lan, MWL Wan, S Hickman… - The Innovation, 2022 - cell.com
Long-term ozone (O 3) exposure may lead to non-communicable diseases and increase
mortality risk. However, cohort-based studies are relatively rare, and inconsistent exposure …

Outdoor air pollution and new-onset airway disease. An official American Thoracic Society workshop report

GD Thurston, JR Balmes, E Garcia… - Annals of the …, 2020 - atsjournals.org
Although it is well accepted that air pollution exposure exacerbates preexisting airway
disease, it has not been firmly established that long-term pollution exposure increases the …

Composition of air pollution particles and oxidative stress in cells, tissues, and living systems

AJ Ghio, MS Carraway, MC Madden - Journal of Toxicology and …, 2012 - Taylor & Francis
Epidemiological studies demonstrated an association between increased levels of ambient
air pollution particles and human morbidity and mortality. Production of oxidants, either …

A critical review of approaches and limitations of inhalation bioavailability and bioaccessibility of metal (loid) s from ambient particulate matter or dust

F Kastury, E Smith, AL Juhasz - Science of the total environment, 2017 - Elsevier
Inhalation of metal (loid) s in ambient particulate matter (APM) represents a significant
exposure pathway to humans. Although exposure assessment associated with this pathway …

Ambient particle inhalation and the cardiovascular system: potential mechanisms.

K Donaldson, V Stone, A Seaton… - Environmental health …, 2001 - ehp.niehs.nih.gov
Well-documented air pollution episodes throughout recent history have led to deaths among
individuals with cardiovascular and respiratory disease. Although the components of air …

Effects of metals within ambient air particulate matter (PM) on human health

LC Chen, M Lippmann - Inhalation toxicology, 2009 - Taylor & Francis
We review literature providing insights on health-related effects caused by inhalation of
ambient air particulate matter (PM) containing metals, emphasizing effects associated with in …

Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children

L Liu, R Poon, L Chen, AM Frescura… - Environmental …, 2009 - ehp.niehs.nih.gov
Background Air pollution is associated with respiratory symptoms, lung function decrements,
and hospitalizations. However, there is little information about the influence of air pollution …

Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public …

M Lippmann - Critical reviews in toxicology, 2014 - Taylor & Francis
Recent investigations on PM2. 5 constituents' effects in community residents have
substantially enhanced our knowledge on the impacts of specific components, especially the …

Synergistic and antagonistic interactions among the particulate matter components in generating reactive oxygen species based on the dithiothreitol assay

H Yu, J Wei, Y Cheng, K Subedi… - Environmental science & …, 2018 - ACS Publications
We assessed the interactions among the particulate matter (PM) components in generating
the reactive oxygen species (ROS) based on a dithiothreitol (DTT) assay. We started with the …