New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFRWT and EGFRT790M Inhibitors: Microwave-Assisted Synthesis …

HE Hashem, AEGE Amr, ES Nossier, MM Anwar… - ACS …, 2022 - ACS Publications
A new series of benzimidazole, 1, 2, 4-triazole, and 1, 3, 5-triazine derivatives were
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …

Quinazolines annelated at the N (3)-C (4) bond: synthesis and biological activity

EV Nosova, GN Lipunova, YV Permyakova… - European Journal of …, 2024 - Elsevier
This review covers article and patent data obtained mostly within the period 2013− 2023 on
the synthesis and biological activity of quinazolines [c]-annelated by five-and six-membered …

Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological …

SM Al-Muntaser, AA Al-Karmalawy, AM El-Naggar… - RSC …, 2023 - pubs.rsc.org
In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …

Docking studies of some novel Hetrocyclic compound as Acat inhibitors: A meta analysis

R Kumar, P Saha, E Keshamma… - Journal for Research in …, 2022 - jrasb.com
We use molecular modelling and pharmacological testing to identify TCM compounds that
may suppress SQS activity. By utilising previously established SQS inhibitors, ten HipHop …

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and …

IMM Othman, ZM Alamshany, NY Tashkandi… - RSC …, 2022 - pubs.rsc.org
Deregulation of various protein kinases is considered as one of the important factors
resulting in cancer development and metastasis, thus multi-targeting the kinase family is one …

Novel 1, 2, 3-triazole-coumarin hybrid glycosides and their tetrazolyl analogues: design, anticancer evaluation and molecular docking targeting EGFR, VEGFR-2 and …

WA El-Sayed, FM Alminderej, MM Mounier, ES Nossier… - Molecules, 2022 - mdpi.com
This study represents the design and synthesis of a new set of triazole-coumarin-glycosyl
hybrids and their tetrazole hybrid analogues possessing various sugar moieties and …

New 1, 2, 3-Triazole-Coumarin-Glycoside Hybrids and Their 1, 2, 4-triazolyl thioglycoside analogs targeting mitochondria apoptotic pathway: Synthesis, anticancer …

WA El-Sayed, FM Alminderej, MM Mounier, ES Nossier… - Molecules, 2022 - mdpi.com
Toxicity and resistance to newly synthesized anticancer drugs represent a challenging
phenomenon of intensified concern arising from variation in drug targets and consequently …

Novel pyridine-thiazolidinone-triazole hybrid glycosides targeting EGFR and CDK-2: Design, synthesis, anticancer evaluation, and molecular docking simulation

AF Kassem, MA Omar, ES Nossier, HM Awad… - Journal of Molecular …, 2023 - Elsevier
The observed toxicity of newly designed anticancer drugs is considered as an impediment
challenging phenomenon of intense concern arising from diversity in drug targets and the …

Current scenario of pyrazole hybrids with anti‐breast cancer therapeutic applications

M Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer stands as the leading cause of cancer‐related deaths among women globally,
but current therapy is restricted to the serious adverse effects and multidrug resistance …

[HTML][HTML] Triazoloquinazoline: Synthetic Strategies and Medicinal Importance

T Jabeen, S Aslam, M Ahmad, A ul Haq, SA Al-Hussain… - 2023 - intechopen.com
Triazoloquinazoline is a fused heterocyclic nucleus, formed by the fusion of two fundamental
heterocyclic moieties; triazole and quinazoline. This class of compound is known for its …