T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
[HTML][HTML] T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
CA Klebanoff, SS Chandran, BM Baker… - Nature Reviews Drug …, 2023 - nature.com
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA
Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes
derived from recurrently mutated driver genes. Here we describe a high-throughput platform …
derived from recurrently mutated driver genes. Here we describe a high-throughput platform …
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
The T cells of the immune system can target tumors and clear solid cancers following tumor-
infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a …
infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a …
T cell receptor‐based cancer immunotherapy: emerging efficacy and pathways of resistance
SS Chandran, CA Klebanoff - Immunological reviews, 2019 - Wiley Online Library
Adoptive cell transfer (ACT) using chimeric antigen receptor (CAR)‐modified T cells can
induce durable remissions in patients with refractory B‐lymphoid cancers. By contrast …
induce durable remissions in patients with refractory B‐lymphoid cancers. By contrast …
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
A Poole, V Karuppiah, A Hartt, JN Haidar… - Nature …, 2022 - nature.com
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal
targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and …
targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and …
[HTML][HTML] MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
A Kurioka, JE Ussher, C Cosgrove, C Clough… - Mucosal …, 2015 - Elsevier
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
Why must T cells be cross-reactive?
AK Sewell - Nature Reviews Immunology, 2012 - nature.com
Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
[HTML][HTML] Bispecific T-cell engagers: towards understanding variables influencing the in vitro potency and tumor selectivity and their modulation to enhance their …
D Ellerman - Methods, 2019 - Elsevier
Bispecific molecules redirecting the cytotoxicity of T-cells are a growing class of therapeutics
with numerous molecules being tested in clinical trials. However, it has been a long way …
with numerous molecules being tested in clinical trials. However, it has been a long way …
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune
system. When the TCR engages a peptide bound to the restricting major histocompatibility …
system. When the TCR engages a peptide bound to the restricting major histocompatibility …