Cellular and extracellular components in tumor microenvironment and their application in early diagnosis of cancers

R Wei, S Liu, S Zhang, L Min… - Analytical Cellular …, 2020 - Wiley Online Library
Tumors are surrounded by complex environmental components, including blood and lymph
vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and …

Nucleic acids analysis

Y Zhao, X Zuo, Q Li, F Chen, YR Chen, J Deng… - Science China …, 2021 - Springer
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and
express genetic information, which play central roles in diverse cellular events and diseases …

A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples

H Zhao, S Pan, A Natalia, X Wu, CAJ Ong… - Nature Biomedical …, 2023 - nature.com
The utility of mechanical metamaterials for biomedical applications has seldom been
explored. Here we show that a metamaterial that is mechanically responsive to antibody …

Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy

S Pan, Y Zhang, A Natalia, CZJ Lim, NRY Ho… - Nature …, 2021 - nature.com
Current technologies to measure drug–target interactions require complex processing and
invasive tissue biopsies, limiting their clinical utility for cancer treatment monitoring. Here we …

Intracellular entropy‐driven multi‐bit DNA computing for tumor progression discrimination

M Bai, F Chen, X Cao, Y Zhao, J Xue… - Angewandte Chemie …, 2020 - Wiley Online Library
Tumor progressions such as metastasis are complicated events that involve abnormal
expression of different miRNAs and enzymes. Monitoring these biomolecules in live cells …

[HTML][HTML] DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules

W Wang, M Lin, W Wang, Z Shen, ZS Wu - Bioactive Materials, 2024 - Elsevier
DNA not only plays a vital role in nature as fundamental hereditary material for storing
genetic material, but also serves as well-defined functional material, for example, building …

Enhancing the sensitivity of photoelectrochemical DNA biosensing using plasmonic DNA barcodes and differential signal readout

A Victorious, S Saha, R Pandey… - Angewandte …, 2021 - Wiley Online Library
Photoelectrochemical biosensors hold great promise for sensitive bioanalysis; however,
similar to their electrochemical analogues, they are highly affected by the variable …

Advancing breast cancer heterogeneity analysis: Insights from genomics, transcriptomics and proteomics at bulk and single-cell levels

Z Zhu, L Jiang, X Ding - Cancers, 2023 - mdpi.com
Simple Summary This review discusses the heterogeneity of breast cancer and strategies to
understand it using multi-omics profiling methods at the traditional bulk and single-cell …

Exosome-templated nanoplasmonics for multiparametric molecular profiling

X Wu, H Zhao, A Natalia, CZJ Lim, NRY Ho… - Science …, 2020 - science.org
Exosomes are nanoscale vesicles distinguished by characteristic biophysical and
biomolecular features; current analytical approaches, however, remain univariate. Here, we …

Progress in biomedical applications of tetrahedral framework nucleic acid-based functional systems

T Zhang, W Cui, T Tian, S Shi, Y Lin - ACS Applied Materials & …, 2020 - ACS Publications
The past decades have witnessed the development of DNA nanotechnology and the
emergence of various spatial DNA nanostructures, from two-dimensions to three …