The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …

The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …

Obesity and its metabolic sequelae still comprise a challenge when it comes to
understanding mechanisms, which drive these pandemic diseases. The human microbiome …

Regulatory T cells (Treg) are known to be critical for the maintenance of immune
homeostasis by suppressing the activation of auto-or allo-reactive effector T cells through a …

Diabetic kidney disease (DKD) is the major reason of chronic kidney disease (CKD)-caused
end-stage renal failure (ESRF), and leads to high mortality worldwide. At present, the …

Accumulating evidence reveals that both inflammation and lymphocyte dysfunction play a
vital role in the development of diabetic nephropathy (DN). Hyperoside (HPS) or quercetin-3 …

Accumulating evidence has implicated that berberine (BBR) has a beneficial effect on
diabetic kidney disease (DKD), but its mechanism is not clear. The aim of this study was to …

Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in
the plasma membrane, and cells swell, rupture, and then release their contents, including …

Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and
has gradually become a public health problem worldwide. DKD is increasingly recognized …

Obesity, a growing chronic metabolic disease, greatly increases the risk of metabolic
syndrome which includes type 2 diabetes, fatty liver and cardiovascular diseases. Obesity …