RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …

Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently
identified> 1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs …

Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

Prediction of protein–RNA interactions is important to understand post-transcriptional events
taking place in the cell. Here we introduce cat RAPID omics v2. 0, an update of our web …

Nucleotide variants can cause functional changes by altering protein–RNA binding in
various ways that are not easy to predict. This can affect processes such as splicing, nuclear …

Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …

Summary 3′ untranslated region (3′ UTR) somatic mutations represent a largely
unexplored avenue of alternative oncogenic gene dysregulation. To determine the …