Communication between cells reaches its highest degree of specialization at chemical
synapses. Some synapses talk in a'whisper'; others' shout'. The'louder'the synapse, the more …

Based on evidence that the docked and primed synaptic vesicle state is very dynamic, we
propose a three-step process for the buildup of the molecular machinery that mediates …

To increase the temporal resolution and maximal imaging time of super-resolution (SR)
microscopy, we have developed a deconvolution algorithm for structured illumination …

Ca2+ triggers many forms of exocytosis in different types of eukaryotic cells, for example
synaptic vesicle exocytosis in neurons, granule exocytosis in mast cells, and hormone …

Hearing in mammals relies on the highly synchronous synaptic transfer between cochlear
inner hair cells (IHCs) and the auditory nerve. We studied the presynaptic function of single …

Throughout the brain, postsynaptic neurons release substances from their cell bodies and
dendrites that regulate the strength of the synapses they receive. Diverse chemical …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of
insulin secretion. In the present study we combined electron microscopy, insulin secretion …

Secretory vesicles dock at the plasma membrane before Ca 2+ triggers their exocytosis.
Exocytosis requires the assembly of SNARE complexes formed by the vesicle protein …