The diversification of methods for studying cell–cell interactions and communication
No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships
DR Plichta, DB Graham, S Subramanian, RJ Xavier - Cell, 2019 - cell.com
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …
complex interaction between host genetics, host immunity, microbiome, and environmental …
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning
The> 800 human G protein–coupled receptors (GPCRs) are responsible for transducing
diverse chemical stimuli to alter cell state-and are the largest class of drug targets. Their …
diverse chemical stimuli to alter cell state-and are the largest class of drug targets. Their …
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples
Frequent and widespread testing of members of the population who are asymptomatic for
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for the …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for the …
[HTML][HTML] Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
H Chen, CE Rosen, JA González-Hernández, D Song… - Cell, 2023 - cell.com
The human body contains thousands of metabolites derived from mammalian cells, the
microbiota, food, and medical drugs. Many bioactive metabolites act through the …
microbiota, food, and medical drugs. Many bioactive metabolites act through the …
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane
receptors in eukaryotes and detect a wide array of cues in the human body. Here we …
receptors in eukaryotes and detect a wide array of cues in the human body. Here we …
Advances in G protein-coupled receptor high-throughput screening
EA Yasi, NS Kruyer, P Peralta-Yahya - Current opinion in biotechnology, 2020 - Elsevier
G protein-coupled receptors (GPCRs) detect compounds on the cell surface and are the
starting point of a number of medically relevant signaling cascades. Indeed, over 30% of …
starting point of a number of medically relevant signaling cascades. Indeed, over 30% of …
[HTML][HTML] Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due
to the high rates of transmission by individuals who are asymptomatic at the time of …
to the high rates of transmission by individuals who are asymptomatic at the time of …
A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell
MLRT Segura, E Abou Moussa, E Garabello… - Cell Reports, 2022 - cell.com
The sense of smell helps us navigate the environment, but its molecular architecture and
underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) …
underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) …
Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes
B Lengger, MK Jensen - FEMS Yeast Research, 2020 - academic.oup.com
ABSTRACT G protein-coupled receptors (GPCRs) comprise the largest class of membrane
proteins in the human genome, with a common denominator of seven-transmembrane …
proteins in the human genome, with a common denominator of seven-transmembrane …