No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

The> 800 human G protein–coupled receptors (GPCRs) are responsible for transducing
diverse chemical stimuli to alter cell state-and are the largest class of drug targets. Their …

Frequent and widespread testing of members of the population who are asymptomatic for
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for the …

The human body contains thousands of metabolites derived from mammalian cells, the
microbiota, food, and medical drugs. Many bioactive metabolites act through the …

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane
receptors in eukaryotes and detect a wide array of cues in the human body. Here we …

G protein-coupled receptors (GPCRs) detect compounds on the cell surface and are the
starting point of a number of medically relevant signaling cascades. Indeed, over 30% of …

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due
to the high rates of transmission by individuals who are asymptomatic at the time of …

The sense of smell helps us navigate the environment, but its molecular architecture and
underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) …

ABSTRACT G protein-coupled receptors (GPCRs) comprise the largest class of membrane
proteins in the human genome, with a common denominator of seven-transmembrane …