The impact of inherited retinal diseases in the Republic of Ireland (ROI) and the United Kingdom (UK) from a cost-of-illness perspective

O Galvin, G Chi, L Brady, C Hippert… - Clinical …, 2020 - Taylor & Francis
To date, there has been a global lack of data regarding the prevalence of conditions falling
under the Inherited Retinal Diseases (IRD) classification, the impact on the individuals and …

Choroidal vascularity index: a step towards software as a medical device

BK Betzler, J Ding, X Wei, JM Lee, DS Grewal… - British Journal of …, 2022 - bjo.bmj.com
The choroidal vascularity index (CVI) is a relatively new parameter, calculated off optical
coherence tomography (OCT) images, for the quantitative evaluation of choroid vascularity …

Visual impairment and risk of depression: A longitudinal follow-up study using a national sample cohort

HG Choi, MJ Lee, SM Lee - Scientific reports, 2018 - nature.com
The association of visual impairment and depression has been investigated in several
studies based on a cross-sectional design, which cannot delineate temporal relationships. In …

Leber hereditary optic neuropathy: review of treatment and management

R Hage, C Vignal-Clermont - Frontiers in Neurology, 2021 - frontiersin.org
Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease
that specifically targets the retinal ganglion cells by reducing their ability to produce enough …

Visual impairment and psychological distress among adults attending the University of Gondar tertiary eye care and training center, Northwest Ethiopia: A comparative …

MB Munaw, MT Tegegn - PloS one, 2022 - journals.plos.org
Background Visual impairment can severely affect the quality of life, with a tremendous
negative impact on job performance and socioeconomic status. This substantially affects the …

[HTML][HTML] Demographics of a large international population of patients affected by Leber's hereditary optic neuropathy

L Poincenot, AL Pearson, R Karanjia - Ophthalmology, 2020 - Elsevier
Purpose To study the demographics of Leber's hereditary optic neuropathy (LHON) using a
large international database of people affected by LHON. Design Cross-sectional study …

Disability Severity, Professional Isolation Perceptions, and Career Outcomes: When Does Leader–Member Exchange Quality Matter?

BJ Lyons, DC Baldridge, LQ Yang… - Journal of …, 2023 - journals.sagepub.com
Employees with disability-related communication impairment often experience isolation from
professional connections that can negatively affect their careers. Management research …

Solutions to a Radical Problem: Overview of Current and Future Treatment Strategies in Leber's Hereditary Opic Neuropathy

SJ Spiegel, AA Sadun - International journal of molecular sciences, 2022 - mdpi.com
Leber's Hereditary Optic Neuropathy (LHON) is the most common primary mitochondrial
DNA disorder. It is characterized by bilateral severe central subacute vision loss due to …

Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression

W Wu, D Howard, E Sibille, L French - Translational psychiatry, 2021 - nature.com
Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and
affects individuals of all ages. It causes significant psychosocial impairments and is a major …

Bidirectional associations of vision loss, hearing loss, and dual sensory loss with depressive symptoms among the middle-aged and older adults in China

W Liu, C Yang, L Liu, G Kong, L Zhang - Journal of Affective Disorders, 2022 - Elsevier
Background Most studies on the relationship between sensory loss and depression focus on
the unidirectional association between sensory loss and the risk of depression based on …