Chronic kidney disease

P Romagnani, G Remuzzi, R Glassock… - Nature reviews Disease …, 2017 - nature.com
Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural
abnormalities or impaired excretory renal function suggestive of a loss of functional …

Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome

S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

[HTML][HTML] Novel biomarkers in the diagnosis of chronic kidney disease and the prediction of its outcome

J Rysz, A Gluba-Brzózka, B Franczyk… - International journal of …, 2017 - mdpi.com
In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent.
Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed …

CE‐MS for metabolomics: Developments and applications in the period 2018–2020

W Zhang, R Ramautar - Electrophoresis, 2021 - Wiley Online Library
Capillary electrophoresis‐mass spectrometry (CE‐MS) is now a mature analytical technique
in metabolomics, notably for the efficient profiling of polar and charged metabolites. Over the …

Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

A Latosinska, J Siwy, H Mischak, M Frantzi - Electrophoresis, 2019 - Wiley Online Library
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …

[HTML][HTML] A survey of machine learning in kidney disease diagnosis

J Qezelbash-Chamak, S Badamchizadeh… - Machine Learning with …, 2022 - Elsevier
Applications of Machine learning (ML) in health informatics have gained increasing
attention. The timely diagnosis of kidney disease and the subsequent immediate response …

Capillary electrophoresis-mass spectrometry at trial by metabo-ring: effective electrophoretic mobility for reproducible and robust compound annotation

N Drouin, M Van Mever, W Zhang, E Tobolkina… - Analytical …, 2020 - ACS Publications
Capillary zone electrophoresis-mass spectrometry (CE-MS) is a mature analytical tool for the
efficient profiling of (highly) polar and ionizable compounds. However, the use of CE-MS in …

Urine proteomics for prediction of disease progression in patients with IgA nephropathy

M Rudnicki, J Siwy, R Wendt… - Nephrology Dialysis …, 2022 - academic.oup.com
Background Risk of kidney function decline in immunoglobulin A (IgA) nephropathy (IgAN) is
significant and may not be predicted by available clinical and histological tools. To serve this …

[HTML][HTML] Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

P Magalhães, M Pejchinovski, K Markoska… - Scientific Reports, 2017 - nature.com
Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A
hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of …

Peptides as “better biomarkers”? Value, challenges, and potential solutions to facilitate implementation

A Latosinska, M Frantzi, J Siwy - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Peptides carry important functions in normal physiological and pathophysiological
processes and can serve as clinically useful biomarkers. Given the ability to diffuse …