The biological function and significance of CD74 in immune diseases

H Su, N Na, X Zhang, Y Zhao - Inflammation Research, 2017 - Springer
Abstract CD74 (MHC class II invariant chain, Ii) is a non-polymorphic type II transmembrane
glycoprotein. It is clear that, in addition to be an MHC class II chaperone, CD74 has a …

[HTML][HTML] Role of MIF cytokine/CD74 receptor pathway in protecting against injury and promoting repair

L Farr, S Ghosh, S Moonah - Frontiers in immunology, 2020 - frontiersin.org
Wound healing after an injury is essential for life. An in-depth understanding of the healing
process is necessary to ultimately improve the currently limited treatment options for patients …

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

DE Harrison, R Strong, P Reifsnyder, N Kumar… - Aging cell, 2021 - Wiley Online Library
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐
feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19%(p< …

The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery

C Stoppe, L Averdunk, A Goetzenich… - Science translational …, 2018 - science.org
Acute kidney injury (AKI) represents the most frequent complication after cardiac surgery.
Macrophage migration inhibitory factor (MIF) is a stress-regulating cytokine that was shown …

Single-cell expression atlas reveals cell heterogeneity in the creeping fat of Crohn's disease

W Shu, Y Wang, C Li, L Zhang… - Inflammatory Bowel …, 2023 - academic.oup.com
Abstract Background Creeping fat (CrF) has been recognized to play a positive role in
Crohn's disease (CD) progression, yet the cellular compositions within mesenteric adipose …

Macrophage migration inhibitory factor regulates U1 small nuclear RNP immune complex–mediated activation of the NLRP3 Inflammasome

MS Shin, Y Kang, ER Wahl, HJ Park… - Arthritis & …, 2019 - Wiley Online Library
Objective High‐expression alleles of macrophage migration inhibitory factor (MIF) are linked
genetically to the severity of systemic lupus erythematosus (SLE). The U1 small nuclear …

[HTML][HTML] The role of CD74 in cardiovascular disease

QL Li, J Tang, L Zhao, A Ruze, XF Shan… - Frontiers in …, 2023 - frontiersin.org
Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular
chaperone of major histocompatibility complex class II (MHC II) molecules involved in …

Stress promotes the infiltration of peripheral immune cells to the brain

EM Medina-Rodriguez, D Han, J Lowell… - Brain, behavior, and …, 2023 - Elsevier
Immune cells and the brain have a privileged interaction. Here, we report changes in the
hippocampal immune microenvironment at the single cell level after stress, uncovering the …

[HTML][HTML] Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture

B Othman, L Zeef, T Szestak, Z Rchiad, J Storm… - Plos one, 2023 - journals.plos.org
The human malaria parasite Plasmodium falciparum is responsible for the majority of
mortality and morbidity caused by malaria infection and differs from other human malaria …

[HTML][HTML] A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity

PV Tilstam, G Pantouris, M Corman, M Andreoli… - Journal of Biological …, 2019 - ASBMB
Cytokine macrophage migration inhibitory factor-2 (MIF-2 or D-dopachrome tautomerase) is
a recently characterized second member of the MIF cytokine superfamily in mammalian …