[HTML][HTML] Global epidemiology of Plasmodium vivax

RE Howes, KE Battle, KN Mendis… - The American journal …, 2016 - ncbi.nlm.nih.gov
Plasmodium vivax is the most widespread human malaria, putting 2.5 billion people at risk of
infection. Its unique biological and epidemiological characteristics pose challenges to …

Evidence and implications of mortality associated with acute Plasmodium vivax malaria

JK Baird - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Vivax malaria threatens patients despite relatively low-grade parasitemias in peripheral
blood. The tenet of death as a rare outcome, derived from antiquated and flawed clinical …

[HTML][HTML] Hidden biomass of intact malaria parasites in the human spleen

S Kho, L Qotrunnada, L Leonardo… - … England Journal of …, 2021 - Mass Medical Soc
Malaria and the Spleen In this report, patients living in a malaria-endemic area underwent
trauma-related splenectomy. In these asymptomatic patients who were naturally infected …

Bone marrow is a major parasite reservoir in Plasmodium vivax infection

N Obaldia III, E Meibalan, JM Sa, S Ma, MA Clark… - MBio, 2018 - Am Soc Microbiol
Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide.
Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation …

[HTML][HTML] Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

H Toda, M Diaz-Varela, J Segui-Barber… - Nature …, 2020 - nature.com
Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies
have shown that circulating microparticles during P. vivax acute attacks are indirectly …

The immunological balance between host and parasite in malaria

K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

[HTML][HTML] Plasmodium vivax–How hidden reservoirs hinder global malaria elimination

F Angrisano, LJ Robinson - Parasitology International, 2022 - Elsevier
Plasmodium vivax is the most geographically widespread human malaria parasite. Global
malaria efforts have been less successful at reducing the burden of P. vivax compared to P …

[HTML][HTML] Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human …

S Kho, L Qotrunnada, L Leonardo, B Andries… - PLoS …, 2021 - journals.plos.org
Background A very large biomass of intact asexual-stage malaria parasites accumulates in
the spleen of asymptomatic human individuals infected with Plasmodium vivax. The …

[HTML][HTML] African Plasmodium vivax malaria improbably rare or benign

JK Baird - Trends in Parasitology, 2022 - cell.com
The overwhelming dominance of Duffy blood group negativity among most people living in
sub-Saharan Africa has been considered the basis of their protection from endemic …

[HTML][HTML] Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria

BE Barber, T William, MJ Grigg… - PLoS …, 2015 - journals.plos.org
Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly
understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal …