Autoimmunity occurs when the immune system recognizes and attacks host tissue. In
addition to genetic factors, environmental triggers (in particular viruses, bacteria and other …

Diagnosis of individuals infected by Trypanosoma cruzi is performed mainly by serological
tests using crude antigens, which might crossreact with other infections. In the past ten …

One-third of all Trypanosoma cruzi-infected patients eventually develop chronic Chagas'
disease cardiomyopathy (CCC), a particularly lethal inflammatory dilated cardiomyopathy …

Heart tissue destruction in chronic Chagas' disease cardiomyopathy (CCC) may be caused
by autoimmune recognition of heart tissue by a mononuclear cell infiltrate decades after …

Heart tissue destruction in chronic Chagas disease cardiopathy (CCC) may be caused by
autoimmune recognition of heart tissue by a mononuclear cell infiltrate decades after …

The notion that the pathology of Chagas' disease has an autoimmune component was
initially based on the finding of circulating antibodies binding heart tissue antigens in …

Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in
Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy …

The commercially available diagnostic tests for Chagas' disease employ whole extracts or
semipurified fractions of Trypanosoma cruzi epimastigotes. Considerable variation in the …

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is an important public
health problem, occurring mainly in Latin America. The disease has a major social and …

Chagas Disease is an important neglected tropical disease caused by Trypanosoma cruzi.
There is no gold standard for diagnosis and commercial serological tests perform poorly in …