Blood–brain barrier dysfunction in mild traumatic brain injury: evidence from preclinical murine models

Y Wu, H Wu, X Guo, B Pluimer, Z Zhao - Frontiers in Physiology, 2020 - frontiersin.org
Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a
robust environmental risk factor for neurodegenerative diseases including Alzheimer's …

Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds

BR Lins, CC Anyaegbu, SC Hellewell, M Papini… - Journal of …, 2023 - Springer
Traumatic brain injury is common, and often results in debilitating consequences. Even mild
traumatic brain injury leaves approximately 20% of patients with symptoms that persist for …

Effects of sub-concussion on neuropsychological performance and its potential mechanisms: a narrative review

S Rawlings, R Takechi, AP Lavender - Brain Research Bulletin, 2020 - Elsevier
Concussion and mild traumatic brain injury (mTBI) are recognised as serious medical events
that are relatively common in contact sports. Recently, the seemingly non-injurious …

Experimental designs for repeated mild traumatic brain injury: challenges and considerations

AN Bolton-Hall, WB Hubbard… - Journal of neurotrauma, 2019 - liebertpub.com
Mild traumatic brain injury (mild TBI) is a growing public concern, as evidence mounts that
even brain injuries classified as “mild” can result in persistent neurological dysfunction …

Acute mitochondrial impairment underlies prolonged cellular dysfunction after repeated mild traumatic brain injuries

WB Hubbard, B Joseph, M Spry, HJ Vekaria… - Journal of …, 2019 - liebertpub.com
Mild traumatic brain injuries (mTBI), accounting for more than 80% of TBIs, can cause
cognitive and behavioral impairments, the severity and duration of which increase after …

Assessment of long-term effects of sports-related concussions: biological mechanisms and exosomal biomarkers

A Ledreux, MK Pryhoda, K Gorgens… - Frontiers in …, 2020 - frontiersin.org
Concussion or mild traumatic brain injury (mTBI) in athletes can cause persistent symptoms,
known as post-concussion syndrome (PCS), and repeated injuries may increase the long …

Blood–brain barrier disruption and ventricular enlargement are the earliest neuropathological changes in rats with repeated sub-concussive impacts over 2 weeks

B Hiles-Murison, AP Lavender, MJ Hackett… - Scientific Reports, 2021 - nature.com
Repeated sub-concussive impact (eg. soccer ball heading), a significantly lighter form of
mild traumatic brain injury, is increasingly suggested to cumulatively alter brain structure and …

Repeated long-term sub-concussion impacts induce motor dysfunction in rats: a potential rodent model

AP Lavender, S Rawlings, A Warnock… - Frontiers in …, 2020 - frontiersin.org
Whilst detrimental effects of repeated sub-concussive impacts on neurophysiological and
behavioral function are increasingly reported, the underlying mechanisms are largely …

Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?

BD Semple, O Panagiotopoulou - Neurotrauma reports, 2023 - liebertpub.com
Mild traumatic brain injuries (TBIs), particularly when repetitive in nature, are increasingly
recognized to have a range of significant negative implications for brain health. Much of the …

Damage mechanisms to oligodendrocytes and white matter in central nervous system injury: the Australian context

A Warnock, LM Toomey, AJ Wright, K Fisher… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) and spinal cord injury (SCI) present a significant contribution to
the global disease burden. White matter tracts are susceptible to both the physical forces of …