Methylmercury-induced neurotoxicity and apoptosis

S Ceccatelli, E Daré, M Moors - Chemico-biological interactions, 2010 - Elsevier
Methylmercury is a widely distributed environmental toxicant with detrimental effects on the
developing and adult nervous system. Due to its accumulation in the food chain, chronic …

Neurotoxicity and the global worst pollutants: astroglial involvement in arsenic, lead, and mercury intoxication

G de Paula Arrifano, ME Crespo-Lopez… - Neurochemical …, 2023 - Springer
Environmental pollution is a global threat and represents a strong risk factor for human
health. It is estimated that pollution causes about 9 million premature deaths every year …

Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

H Lohren, L Blagojevic, R Fitkau, F Ebert… - Journal of Trace …, 2015 - Elsevier
Organic mercury (Hg) species exert their toxicity primarily in the central nervous system. The
food relevant Hg species methylmercury (MeHg) has been frequently studied regarding its …

Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells

M Farina, F Campos, I Vendrell… - Toxicological …, 2009 - academic.oup.com
Methylmercury (MeHg) is an environmental neurotoxicant whose molecular mechanisms
underlying toxicity remain elusive. Here, we investigated molecular events involved in MeHg …

Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors

F Xu, S Farkas, S Kortbeek, FX Zhang, L Chen… - Molecular brain, 2012 - Springer
Background Mercury is a well-known neurotoxin implicated in a wide range of neurological
or psychiatric disorders including autism spectrum disorders, Alzheimer's disease …

Insights into the potential role of mercury in Alzheimer's disease

G Bjørklund, AA Tinkov, M Dadar, MM Rahman… - Journal of Molecular …, 2019 - Springer
Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for
biological systems even when present at trace levels. Elevated Hg exposure with the …

Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin

JL Franco, HC Braga, J Stringari… - Chemical research in …, 2007 - ACS Publications
Plants of the genus Polygala have been shown to possess protective effects against
neuronal death and cognitive impairments in neurodegenerative disorders related to …

Neurotoxicity of mercury: an old issue with contemporary significance

V Branco, M Aschner, C Carvalho - Advances in neurotoxicology, 2021 - Elsevier
Mercury exerts a variety of toxic effects, depending on the specific compound and route of
exposure. However, neurotoxicity in virtue of its consequence to health causes the greatest …

Hippocampal dysfunction provoked by mercury chloride exposure: evaluation of cognitive impairment, oxidative stress, tissue injury and nature of cell death

WAB Aragão, FB Teixeira… - Oxidative medicine …, 2018 - Wiley Online Library
Mercury (Hg) is a highly toxic metal, which can be found in its inorganic form in the
environment. This form presents lower liposolubility and lower absorption in the body. In …

Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of …

V Karri, D Ramos, JB Martinez, A Odena, E Oliveira… - Journal of …, 2018 - Elsevier
Chronic exposure to heavy metals such as Pb, As, and MeHg can be associated with an
increased risk of developing neurodegenerative diseases. Our in vitro bioassays results …