The genetic history of the Southern Andes from present-day Mapuche ancestry

E Arango-Isaza, MR Capodiferro, MJ Aninao… - Current Biology, 2023 - cell.com
The southernmost regions of South America harbor some of the earliest evidence of human
presence in the Americas. However, connections with the rest of the continent and the …

Disentangling signatures of selection before and after European colonization in Latin Americans

J Mendoza-Revilla, JC Chacón-Duque… - Molecular biology …, 2022 - academic.oup.com
Throughout human evolutionary history, large-scale migrations have led to intermixing (ie,
admixture) between previously separated human groups. Although classical and recent …

Exome Sequencing has a high diagnostic rate in sporadic congenital hypopituitarism and reveals novel candidate genes

J Martinez-Mayer, S Vishnopolska… - The Journal of …, 2024 - academic.oup.com
Context The pituitary gland is key for childhood growth, puberty, and metabolism. Pituitary
dysfunction is associated with a spectrum of phenotypes, from mild to severe. Congenital …

Ancient human genomes and environmental DNA from the cement attaching 2,000-year-old head lice nits

MW Pedersen, C Antunes, B De Cahsan… - Molecular Biology …, 2022 - academic.oup.com
Over the past few decades, there has been a growing demand for genome analysis of
ancient human remains. Destructive sampling is increasingly difficult to obtain for ethical …

Ancient and modern mitogenomes from Central Argentina: new insights into population continuity, temporal depth and migration in South America

A García, R Nores, JMB Motti, M Pauro… - Human Molecular …, 2021 - academic.oup.com
The inverted triangle shape of South America places Argentina territory as a geographical
crossroads between the two principal peopling streams that followed either the Pacific or the …

Comprehensive identification of pathogenic gene variants in patients with neuroendocrine disorders

SA Vishnopolska, MF Mercogliano… - The Journal of …, 2021 - academic.oup.com
Purpose Congenital hypopituitarism (CH) can present in isolation or with other birth defects.
Mutations in multiple genes can cause CH, and the use of a genetic screening panel could …

Nationwide genetic analysis of more than 600 families with inherited eye diseases in Argentina

PG Schlottmann, JD Luna, N Labat… - NPJ Genomic …, 2023 - nature.com
This study corresponds to the first large-scale genetic analysis of inherited eye diseases
(IED) in Argentina and describes the comprehensive genetic profile of a large cohort of …

Patagonian sheepdog: Genomic analyses trace the footprints of extinct UK herding dogs to South America

N Barrios, C González-Lagos, DL Dreger… - PLoS …, 2022 - journals.plos.org
Most modern dog breeds were developed within the last two hundred years, following strong
and recent human selection based predominantly on aesthetics, with few modern breeds …

COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity

LI Onofrio, C Marin, J Dutto, MB Brugo… - Frontiers in …, 2023 - frontiersin.org
This work examines cellular immunity against SARS-CoV-2 in patients from Córdoba,
Argentina, during two major waves characterized by different circulating viral variants and …

[HTML][HTML] Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G

IG Segura, DG Secchi, MF Galíndez… - … Oral, Patología Oral y …, 2022 - ncbi.nlm.nih.gov
Background To our knowledge, there is no useful and accurate prognostic biomarker or
biomarkers for patients with oral squamous cell carcinoma (OSCC), a tumor with uncertain …