Determinants of resistance and response to melanoma therapy
BM Robertson, ME Fane, AT Weeraratna… - Nature Cancer, 2024 - nature.com
Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …
despite immense progress in the way of available therapeutic options and historic …
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8
Y Xiao, N Awasthee, Y Liu, C Meng… - Journal of Medicinal …, 2024 - ACS Publications
HDAC8 plays crucial roles in biological processes, from gene regulation to cell motility,
making it a highly desirable target for therapeutic intervention. HDAC8 also has deacetylase …
making it a highly desirable target for therapeutic intervention. HDAC8 also has deacetylase …
HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
Secreted protein acidic and rich in cysteine (SPARC), a conserved secreted glycoprotein,
plays crucial roles in regulating various biological processes. SPARC is highly expressed …
plays crucial roles in regulating various biological processes. SPARC is highly expressed …