The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions
C Zhuo, H Tian, X Song, D Jiang, G Chen, Z Cai… - Schizophrenia, 2023 - nature.com
Cognitive impairment is a core clinical feature of schizophrenia, exerting profound adverse
effects on social functioning and quality of life in a large proportion of patients with …
effects on social functioning and quality of life in a large proportion of patients with …
Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction
Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased
expression of the immune gene C4 has been linked to a greater risk of developing …
expression of the immune gene C4 has been linked to a greater risk of developing …
Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease
Mechanisms underlying the protective effect of apolipoprotein E (APOE) ε2 against
Alzheimer disease (AD) are not well understood. We analyzed gene expression data …
Alzheimer disease (AD) are not well understood. We analyzed gene expression data …
Gamma subunit of complement component 8 is a neuroinflammation inhibitor
The complement system is part of the innate immune system that comprises several small
proteins activated by sequential cleavages. The majority of these complement components …
proteins activated by sequential cleavages. The majority of these complement components …
Overexpression of complement component C4 in the dorsolateral prefrontal cortex, parietal cortex, superior temporal gyrus and associative striatum of patients with …
Background In schizophrenia, abnormal synaptic pruning during adolescence may be due
to altered expression of the Complement component 4 (C4). Overexpression of C4 genes …
to altered expression of the Complement component 4 (C4). Overexpression of C4 genes …
Complement component C4 levels in the cerebrospinal fluid and plasma of patients with schizophrenia
JA Gallego, EA Blanco, C Morell, T Lencz… - …, 2021 - nature.com
Abnormalities in the complement system have been described in patients with
schizophrenia, with those individuals having greater frequency of complement component …
schizophrenia, with those individuals having greater frequency of complement component …
Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls
Abstract Changes in immune function are associated with variance in cognitive functioning
in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we …
in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we …
Genetic and inflammatory effects on childhood trauma and cognitive functioning in patients with schizophrenia and healthy participants
Recent studies have reported a negative association between exposure to childhood
trauma, including physical neglect, and cognitive functioning in patients with schizophrenia …
trauma, including physical neglect, and cognitive functioning in patients with schizophrenia …
Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress
The complement cascade is a major component of the immune defence against infection,
and there is increasing evidence for a role of dysregulated complement in major psychiatric …
and there is increasing evidence for a role of dysregulated complement in major psychiatric …