Living organisms use a large repertoire of anabolic and catabolic reactions to maintain their
physiological body functions, many of which include oxidation and reduction of substrates …

One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins
due to changes in proteostasis involving endoplasmic reticulum (ER) stress. To alleviate ER …

The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of
increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor …

The J-domain proteins (JDP) form the largest protein family among cellular chaperones. In
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …

Pulmonary arterial hypertension forms the first and most severe of the 5 categories of
pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of …

Mitochondrial fidelity is a key determinant of longevity and was found to be perturbed in a
multitude of disease contexts ranging from neurodegeneration to heart failure. Tight …

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range
of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein …

Breast cancer, which is the most common malignant tumor among women worldwide and an
important cause of death in women. The existing prognostic model for patients with breast …

Background An emerging component of Unfolded Protein Response (UPR) pathway, cation
transport regulator homolog 1 (CHAC1) has been conferred with the ability to degrade …

Stress granules (SGs) are membraneless organelles composed of mRNAs and RNA binding
proteins which undergo assembly in response to stress-induced inactivation of translation …