Impaired cardiovascular function has recently been demonstrated to potentially reduce life
expectancy both in GH deficiency and excess. Experimental and clinical studies have …

which is influenced by the nature and degree of the overload.(3)[3H] Thymidine labeling
cannot be equated with an increase in cell number.(4) The presence or absence of cell …

ALTHOUGH GH is primarily involved in the regulation of somatic growth, it also participates
in the control number of physiological processes, eg maintenance muscle mass and …

Accumulating evidence has indicated that insulin-like growth factor-1 (IGF-1) plays a specific
role in the intricate cascade of events of cardiovascular function, in addition to its well …

The renin-angiotensin system regulates normal cardiovascular homeostasis and is activated
in certain forms of hypertension and in heart failure. Angiotensin II has multiple physiological …

Transgenic mice were generated in which the cDNA for the human insulin-like growth factor
1B (IGF-1B) was placed under the control of a rat alpha-myosin heavy chain promoter. In …

▪ Abstract Cardiac muscle cells exhibit two related but distinct modes of growth that are
highly regulated during development and disease. Cardiac myocytes rapidly proliferate …

To determine whether additional hypertrophy would be beneficial or maladaptive in cardiac
failure, the effects of insulin-like growth factor (IGF-1) were investigated in rats with left …

Background Despite their increasing clinical use and recent evidence that growth hormone
(GH) and insulin-like growth factor–1 (IGF-1) target the heart, there has been no systematic …

Insulin-like growth factor I (IGF I) is a ubiquitous peptide that has a fundamental role in both
prenatal and postnatal development (reviewed in [1, 2]). It is the major mediator of growth …