Centrosomes—as well as the related spindle pole bodies (SPBs) of yeast—have been
extensively studied from the perspective of their microtubule-organizing roles. Moreover, the …

Simple Summary Cancer is increasingly viewed as a cell cycle disease in that the
dysregulation of the cell cycle machinery is a common feature in cancer. The Hippo …

Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases
worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with …

The metazoan Hippo pathway is an essential tumour suppressor signalling cascade that
ensures normal tissue growth by co-ordinating cell proliferation, cell death and cell …

The family of MOBs (m onopolar spindle-o ne-b inder protein s) is highly conserved in the
eukaryotic kingdom. MOBs represent globular scaffold proteins without any known …

In mammals, the KIBRA locus has been associated with memory performance and cognition
by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila …

The process of platelet production has so far been understood to be a 2-stage process:
megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation …

Recently the ESCRT-III filamentous complex was designated as the driving force for
mammalian cell abscission, that is, fission of the intercellular membrane bridge connecting …

Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can
lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the …

Cytokinesis is initiated by constriction of the cleavage furrow, and completed with separation
of the two daughter cells by abscission. Control of transition from constriction to abscission is …