Mouse models for the study of colon carcinogenesis
The study of experimental colon carcinogenesis in rodents has a long history, dating back
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …
[HTML][HTML] The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies
M De Robertis, E Massi, ML Poeta, S Carotti… - Journal of …, 2011 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a major health problem in industrialized countries. Although
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …
DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice
Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could
play an important role in the initiation and progression of colon cancer. Curcumin, a dietary …
play an important role in the initiation and progression of colon cancer. Curcumin, a dietary …
The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane-and dextran sulfate …
Colorectal cancer (CRC) is the third most common cancer worldwide. Chronic inflammation
appears to enhance the risk of CRC. Emerging evidence has suggested that epigenetic …
appears to enhance the risk of CRC. Emerging evidence has suggested that epigenetic …
Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice
V Megaraj, X Ding, C Fang, N Kovalchuk… - Chemical research in …, 2014 - ACS Publications
P450-mediated bioactivation of azoxymethane (AOM), a colon carcinogen, leads to the
formation of DNA adducts, of which O 6-methylguanine (O6-mG) is the most mutagenic and …
formation of DNA adducts, of which O 6-methylguanine (O6-mG) is the most mutagenic and …
Epigenetics of Dietary Phytochemicals in Cancer Prevention: Fact or Fiction
Cancer development takes 10 to 50 years, and epigenetics plays an important role. Recent
evidence suggests that~ 80% of human cancers are linked to environmental factors …
evidence suggests that~ 80% of human cancers are linked to environmental factors …
Intracellular glutathione mediates the denitrosylation of protein nitrosothiols in the rat spinal cord
JM Romero, OA Bizzozero - Journal of neuroscience research, 2009 - Wiley Online Library
Protein S‐nitrosothiols (PrSNOs) have been implicated in the pathophysiology of
neuroinflammatory and neurodegenerative disorders. Although the metabolically instability …
neuroinflammatory and neurodegenerative disorders. Although the metabolically instability …
Azoxymethane induces KI‐ras activation in the tumor resistant AKR/J mouse colon
AB Bolt, A Papanikolaou, DA Delker… - … in cooperation with …, 2000 - Wiley Online Library
A differential susceptibility phenotype to the organotropic colon carcinogen azoxymethane
(AOM) has been described in mice. The following studies were undertaken to test the …
(AOM) has been described in mice. The following studies were undertaken to test the …
Quantitative assessment of azoxymethane-inducedaberrant crypt foci in inbred mice
DA Delker, QS Wang, A Papanikolao… - Experimental and …, 1999 - Elsevier
Heritable differences in tumor susceptibility are observed in mice after repetitive exposures
to theorganotropic colon carcinogen azoxymethane (AOM). The following study was …
to theorganotropic colon carcinogen azoxymethane (AOM). The following study was …
Diallyl sulfide enhances azoxymethane-induced preneoplasia in Fischer 344 rat colon
DA Delker, A Papanikolaou, YJ Suhr… - Chemico-Biological …, 2000 - Elsevier
Azoxymethane (AOM) is an indirect-acting colon carcinogen that produces a high incidence
of precancerous lesions, referred to as aberrant crypt foci (ACF), in rats. This study was …
of precancerous lesions, referred to as aberrant crypt foci (ACF), in rats. This study was …