The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …

Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating
cytokine and chemokine secretion. However, its function in the tumor microenvironment …

Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …

Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

Metastasis remains the major obstacle to improved survival for breast cancer patients.
Downregulation of FOXO3a transcription factor in breast cancer is causally associated with …

Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly
implicated in cancer, with various critical roles in biological processes. Herein, we provide …

Oxidative stress is a major cause of morbidity and mortality in human health and disease. In
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …