FOXO transcription factors as mediators of stress adaptation
MJ Rodriguez-Colman, TB Dansen… - … Reviews Molecular Cell …, 2024 - nature.com
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
The FoxO–autophagy axis in health and disease
Z Cheng - Trends in Endocrinology & Metabolism, 2019 - cell.com
Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has
been implicated in several human diseases including obesity, diabetes, cardiovascular …
been implicated in several human diseases including obesity, diabetes, cardiovascular …
[HTML][HTML] FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma
Y Wang, Z Lyu, Y Qin, X Wang, L Sun, Y Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating
cytokine and chemokine secretion. However, its function in the tumor microenvironment …
cytokine and chemokine secretion. However, its function in the tumor microenvironment …
Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis
MC Ludikhuize, M Meerlo, MP Gallego, D Xanthakis… - Cell metabolism, 2020 - cell.com
Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …
Autophagy and breast cancer: connected in growth, progression, and therapy
Q Wu, D Sharma - Cells, 2023 - mdpi.com
Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …
been consistently improving owing to the development of multiple targeted therapies and …
Targeting undruggable transcription factors with PROTACs: advances and perspectives
Y Li, J Song, P Zhou, J Zhou, S Xie - Journal of Medicinal …, 2022 - ACS Publications
Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …
However, these proteins have traditionally been regarded as undruggable and only a …
SOX9: An emerging driving factor from cancer progression to drug resistance
Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …
FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis
Y Song, S Zeng, G Zheng, D Chen, P Li, M Yang, K Luo… - Oncogene, 2021 - nature.com
Metastasis remains the major obstacle to improved survival for breast cancer patients.
Downregulation of FOXO3a transcription factor in breast cancer is causally associated with …
Downregulation of FOXO3a transcription factor in breast cancer is causally associated with …
The dominant role of forkhead box proteins in cancer
Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly
implicated in cancer, with various critical roles in biological processes. Herein, we provide …
implicated in cancer, with various critical roles in biological processes. Herein, we provide …
FoxO3 and oxidative stress: a multifaceted role in cellular adaptation
VS Bernardo, FF Torres, DGH Da Silva - Journal of Molecular Medicine, 2023 - Springer
Oxidative stress is a major cause of morbidity and mortality in human health and disease. In
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …