Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

Integrins are cell surface transmembrane receptors that recognize and bind to extracellular
matrix proteins and counter receptors. Binding of activated integrins to their ligands induces …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

During CNS development, oligodendrocytes wrap their plasma membrane around axons to
generate multilamellar myelin sheaths. To drive growth at the leading edge of myelin at the …

Dedifferentiation of myelinating Schwann cells is a key feature of nerve injury and
demyelinating neuropathies. We review recent evidence that this dedifferentiation depends …