Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Reactive oxygen species in the mammalian pre-implantation embryo

JC Deluao, Y Winstanley, RL Robker… - …, 2022 - rep.bioscientifica.com
In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

Lipid metabolism in bovine oocytes and early embryos under in vivo, in vitro, and stress conditions

F de Andrade Melo-Sterza, R Poehland - International Journal of …, 2021 - mdpi.com
Lipids are a potential reservoir of energy for initial embryonic development before activation
of the embryonic genome and are involved in plasma membrane biosynthesis. Excessive …

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

W Yang, P Wang, P Cao, S Wang, Y Yang, H Su… - Epigenetics & …, 2021 - Springer
Background Dynamic changes of histone posttranslational modifications are important
contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently …

Unraveling the consequences of oxygen imbalance on early embryo development: Exploring mitigation strategies

TV Marsico, MV Silva, RS Valente, K Annes, VB Rissi… - Animals, 2023 - mdpi.com
Simple Summary Early embryo development is a dynamic and orchestrated event. Oxygen
plays a fundamental role in several key biological processes necessary to sustain and …

The dynamics between in vitro culture and metabolism: embryonic adaptation to environmental changes

CB de Lima, ÉC Dos Santos, J Ispada, PK Fontes… - Scientific Reports, 2020 - nature.com
Previous studies have discussed the importance of an optimal range of metabolic activity
during preimplantation development. To avoid factors than can trigger an undesirable …

Coenzyme Q10 stimulate reproductive vatality

X Nie, X Dong, Y Hu, F Xu, C Hu… - Drug design, development …, 2023 - Taylor & Francis
Female infertility and pregnancy maintenance are associate with various factors, including
quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases …

HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxic regulation of preimplantation embryos: lessons from human embryonic stem cells

FD Houghton - Reproduction, 2021 - rep.bioscientifica.com
Development of the preimplantation embryo is reliant on nutrients present in the milieu of the
reproductive tract. While carbohydrates, amino acids, lipids, and micronutrients are often …

Erasing gametes to write blastocysts: metabolism as the new player in epigenetic reprogramming

MP Milazzotto, CB Lima, AM Fonseca… - Animal …, 2020 - SciELO Brasil
Understanding preimplantation embryonic development is crucial for the improvement of
assisted reproductive technologies and animal production. To achieve this goal, it is …

Oxygen tension during in vitro oocyte maturation and fertilization affects embryo quality in sheep and deer

I Sánchez-Ajofrín, M Iniesta-Cuerda… - Animal reproduction …, 2020 - Elsevier
Incubation gas atmosphere affects the development of in vitro produced embryos. In this
study, there was examination of effects of two different oxygen (O 2) tensions (5% and 21%) …