Autophagy is a conserved method of quality control in which cytoplasmic contents are
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD). However, a potential role of wild-type LRRK2 in idiopathic PD (iPD) remains …

Lipid droplet (LD) functions are regulated by a complement of integral and peripheral
proteins that associate with the bounding LD phospholipid monolayer. Defining the …

Autophagy is an evolutionarily conserved lysosome-or vacuole-dependent catabolic
pathway in eukaryotes. Autophagy functions basally for cellular quality control and is …

The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-
directed process of autophagy. An organelle-selective form of this process (macrolipophagy) …

Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

In cells, lipids are stored in lipid droplets, dynamic organelles that adapt their size,
abundance, lipid and protein composition and organelle interactions to metabolic changes …

Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs).
While the field of lipophagy research is relatively young, an expansion of research in this …