In the past two decades, transition metal-catalyzed C–H functionalization followed by
annulations with various coupling partners has received much attention in organic synthesis …

Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of
methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

We have designed and synthesized three pyrazole analogs (4, 5a, 5b), pyrazole-based
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …

Breast cancer is the second most leading cause of death among women. Multiple drugs
have been approved by FDA for the treatment of BC. The major drawbacks of existing drugs …

In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against
metabolic enzymes including α-glycosidase, acetylcholinesterase, butyrylcholinesterase …

Plant bacteria and viruses have a huge negative impact on food crops in the world.
Therefore, it is important to create new and efficient green pesticides. In this paper, a series …

Main observation and conclusion Novel quinazolonthiazoles were designed and
synthesized as new potential antimicrobial agents by facile multi‐step procedure from o …

We report the synthesis of C6-substituted isoquinolino [1, 2-b] quinazolinones via rhodium
(III)-catalyzed C–H annulation with sulfoxonium ylides and evaluation of the cytotoxic activity …

Although the synthesis of novel N-heterocyclic molecules is extremely demanding as well as
challenging, the involvement of toxic solvents often triggers environmental safety concerns …