In a society where physical activity is limited and food supply is abundant, metabolic
diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

For patients with type 1 diabetes, it is accepted among the scientific community that there is
a marked reduction in β-cell mass; however, with type 2 diabetes, there is disagreement as …

Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or
within the human body, often as multifaceted polymicrobial biofilm communities at mucosal …

Objective: This report examines what is known about the relationship between obesity and
type 2 diabetes and how future research in these areas might be directed to benefit …

Diabetes leads to health problems for hundreds of millions of people globally every year.
Available medical records of patients quantify symptoms, body features, and clinical …

Obesity is associated with an increased risk of developing insulin resistance and type 2
diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified …

Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

In this contribution we put forward a novel hypothesis concerning the aetiology of Type 2
(non-insulin-dependent) diabetes mellitus. The concept underlying our hypothesis is that …