Lens, an avascular tissue involved in light transmission, generates an internal
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …

Charged multivesicular-body protein 4b (CHMP4B) is a core sub-unit of the endosomal
sorting complex required for transport-III (ESCRT-III) machinery that serves myriad …

Cataract is the leading cause of blindness worldwide. Here, we reported a potential,
effective therapeutic mean for cataract prevention and treatment. Gap junction …

Purpose: The mammalian ocular lens is an avascular multicellular organ that grows
continuously throughout life. Traditionally, its cellular organization is investigated using …

Gap junction channels made of different connexins have distinct permeability to second
messengers, which could affect many cell processes, including lens epithelial cell division …

We have investigated how connexin 46 (Cx46) regulates lens stiffness by studying different
Cx46 knockout (Cx46KO) mice. A modified muscle lever system was used to determine the …

Congenital cataract refers to a lens opacity caused by multiple etiological factors, including
genetic mutation, abnormal metabolism of the lens, and infection. Currently, there are> 100 …