Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Diabetic neuropathy is a heterogeneous group of disorders with extremely complex
pathophysiology and affects both somatic and autonomic components of the nervous …

Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

Both cardio-and microvascular complications adversely affect the life quality of patients with
diabetes and have been the leading cause of mortality and morbidity in this population …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Neuropathy is the most common complication of diabetes. As a consequence of
longstanding hyperglycemia, a downstream metabolic cascade leads to peripheral nerve …

Microvascular complications (retinopathy, nephropathy, and neuropathy) affect hundreds of
millions of patients with type 2 diabetes. They usually affect people with longstanding or …

Diabetic neuropathy is not a single entity but rather a number of different syndromes, each
with a range of clinical and subclinical manifestations. According to the San Antonio …

Objective: Sudomotor dysfunction may be an early detectable abnormality in diabetic small
fiber neuropathy. The aim of this study was to evaluate the efficacy of Sudoscan™(Impeto …