Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …

Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Airways inflammation is thought to play a central role in the pathogenesis of asthma.
However, the precise role that individual inflammatory cells and mediators play in the …

Cytokines are usually extracellular signalling proteins, usually less than 80 kD in size, and
many are glycosylated. They are produced by many diVerent cell types that are involved in …

Background Asthma is a chronic inflammatory disease involving diverse cells and mediators
whose interconnectivity and relationships to asthma severity are unclear. Objective We …

Nitric oxide (NO) is a mediator of vasodilatation and bronchodilatation synthesised from L-
arginine by the enzyme NO synthase, which is either constitutive or induced by …

To examine the nature and the degree of airway inflammation in chronic bronchitis during
exacerbations, bronchial biopsies and sputum were obtained in 11 subjects with chronic …

Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic
disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700 …

BACKGROUND: Previously, we found that mast cell tryptases and carboxypeptidase A3
(CPA3) are differentially expressed in the airway epithelium in asthmatic subjects. We also …