Lentiviral vectors are among the most effective viral vectors for vaccination. In clear contrast
to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing …

Introduction Lentiviral vectors have emerged as powerful vectors for vaccination, due to their
high efficiency to transduce dendritic cells and to induce long-lasting humoral immunity …

One million estimated cases of spinal cord injury (SCI) have been reported in the United
States and repairing an injury has constituted a difficult clinical challenge. The complex …

Background Highly pathogenic emerging and re-emerging viruses continuously threaten
lives worldwide. In order to provide prophylactic prevention from the emerging and re …

Gene expression regulation is the result of complex interactions between transcriptional and
post-transcriptional controls, resulting in cell-type-specific gene expression patterns that are …

Our work over the past eight years has focused on the use of HIV-1 lentiviral vectors
(lentivectors) for the genetic modification of dendritic cells (DCs) to control their functions in …

Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss
below the level of injury, including paralysis and loss of bladder, bowel, and sexual function …

Despite the promising features of lentiviral vectors for cancer gene therapy, tumor targeting
remains a major challenge. Incorporation of the specific targeting moieties on the surface of …

Many gene therapy strategies rely on lentiviral-mediated transfer and expression of genes
coding for toxic proteins. Methods of controlling transgene expression in target cells have …

Hepatotropic viruses constitute a global health concern, as the WHO estimates over 300
million people worldwide suffering from chronic viral hepatitis. One of the causative agents is …