Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

One of the major challenges that remain in the fields of aging and lifespan determination
concerns the precise roles that reactive oxygen species (ROS) play in these processes …

Yeast is widely used for industrial production of various types of products, such as ethanol
and enzymes. However, its fermentation efficiency is strongly reduced by harmful …

Abstract l-lactate is a catabolite from the anaerobic metabolism of glucose, which plays a
paramount role as a signaling molecule in various steps of the cell survival. Its activity, as a …

Cells must be able to respond and adapt to different stress conditions to maintain normal
function. A common response to stress is the global inhibition of protein synthesis. Protein …

Redox cycles have been reported in ultradian, circadian and cell cycle-synchronized
systems. Redox cycles persist in the absence of transcription and cyclin-CDK activity …

Enhanced production of reactive oxygen species (ROS) triggered by various stimuli,
including viral infections, has attributed much attention in the past years. It has been shown …

The recently observed circadian oscillations of the intestinal microbiota underscore the
profound nature of the human–microbiome relationship and its importance for health …

Peroxiredoxins (PRDXs) are abundant peroxidases present in all kingdoms of life. Recently,
they have been shown to also carry out additional roles as molecular chaperones. To …