The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

The Wnt and the bone morphogenic protein (BMP) pathways are evolutionarily conserved
and essentially independent signaling mechanisms, which, however, often regulate similar …

Abstract In late 2004, an International Consortium of research groups were charged with the
task of producing a high-quality molecular anatomy of the developing mammalian urogenital …

Human induced pluripotent stem cell (hiPSC)-derived kidney organoids have prospective
applications ranging from basic disease modelling to personalised medicine. However …

The ureteric bud (UB) is an outgrowth of the Wolffian duct, which undergoes a complex
process of growth, branching, and remodeling, to eventually give rise to the entire urinary …

GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud
(UB) branching morphogenesis during kidney development in mice and humans …

The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the
renal collecting system. Although development of a normal kidney depends on proper …

Signaling by GDNF through the Ret receptor tyrosine kinase is required for the normal
growth and morphogenesis of the ureteric bud (UB) during kidney development. Recent …

The mammalian kidney, which at maturity contains thousands of nephrons joined to a highly
branched collecting duct (CD) system, is an important model system for studying the …

The kidney medulla is a specialized region with important homeostatic functions. It has been
implicated in genetic and developmental disorders along with ischemic and drug-induced …