Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Treatments that target immune checkpoints, such as the one mediated by programmed cell
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have recently
entered the therapeutic armamentarium of clinical oncologists, and show promising activity …

Inhibiting the cell-cycle kinases CDK4 and CDK6 results in significant therapeutic effect in
patients with advanced hormone-positive breast cancer. The efficacy of this strategy is …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The cyclin D/cyclin-dependent kinases 4 and 6 (CDK4/6)–retinoblastoma protein (RB)
pathway plays a key role in the proliferation of both normal breast epithelium and breast …

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

Pharmacological inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are now an
established standard of care for patients with advanced hormone receptor-positive breast …